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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PPAPDC1A All Species: 10.91
Human Site: S260 Identified Species: 17.14
UniProt: Q5VZY2 Number Species: 14
    Phosphosite Substitution
    Charge Score: 0.14
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q5VZY2 NP_001025230.1 271 30395 S260 P T A D S A P S L P L E G I T
Chimpanzee Pan troglodytes XP_001170623 223 25141 Q213 K L V L S T A Q K P G D S Y C
Rhesus Macaque Macaca mulatta XP_001092746 343 37863 H319 P L T D A E C H K P F Q D K L
Dog Lupus familis XP_535038 333 36609 S322 P T A D S A P S M P L E G I T
Cat Felis silvestris
Mouse Mus musculus Q0VBU9 271 30425 S260 P T A D S A P S L P L E G I T
Rat Rattus norvegicus O08564 282 31978 E258 K T T E S N K E R K E D S H T
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001514919 461 51675 E266 A H Q D G D E E A T F P R E R
Chicken Gallus gallus XP_426544 322 36285 G311 P T A D N A T G L P L E G I T
Frog Xenopus laevis Q6GQ62 226 25153 K216 M S G A Q E R K L S T P G Y S
Zebra Danio Brachydanio rerio XP_002664129 282 31516 D267 Q D Q P L P T D N A T S L P L
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera XP_623887 268 30640 M257 I H C C V G E M L S Q L P V H
Nematode Worm Caenorhab. elegans Q10022 341 39009 A311 E E R H R L D A V L P S T D S
Sea Urchin Strong. purpuratus XP_787511 258 29394 S247 Y N T N N A I S T R I P L D S
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9XI60 290 32684 L279 D S A G M N H L S V R Q T E L
Baker's Yeast Sacchar. cerevisiae Q05521 289 33495 I276 E A V T H Q R I P D E E L H P
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 51.2 48 77.7 N.A. 99.2 25.5 N.A. 48.1 77.3 52.4 71.2 N.A. N.A. 47.9 24.3 46.1
Protein Similarity: 100 64.9 60 79.8 N.A. 99.2 41.1 N.A. 53.3 80.4 63.4 83.6 N.A. N.A. 66.7 39.8 64.2
P-Site Identity: 100 13.3 20 93.3 N.A. 100 20 N.A. 6.6 80 13.3 0 N.A. N.A. 6.6 0 13.3
P-Site Similarity: 100 20 33.3 100 N.A. 100 33.3 N.A. 6.6 86.6 26.6 0 N.A. N.A. 13.3 20 40
Percent
Protein Identity: N.A. N.A. N.A. 36.5 31.1 N.A.
Protein Similarity: N.A. N.A. N.A. 54.4 50.5 N.A.
P-Site Identity: N.A. N.A. N.A. 6.6 6.6 N.A.
P-Site Similarity: N.A. N.A. N.A. 20 6.6 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 7 7 34 7 7 34 7 7 7 7 0 0 0 0 0 % A
% Cys: 0 0 7 7 0 0 7 0 0 0 0 0 0 0 7 % C
% Asp: 7 7 0 40 0 7 7 7 0 7 0 14 7 14 0 % D
% Glu: 14 7 0 7 0 14 14 14 0 0 14 34 0 14 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 14 0 0 0 0 % F
% Gly: 0 0 7 7 7 7 0 7 0 0 7 0 34 0 0 % G
% His: 0 14 0 7 7 0 7 7 0 0 0 0 0 14 7 % H
% Ile: 7 0 0 0 0 0 7 7 0 0 7 0 0 27 0 % I
% Lys: 14 0 0 0 0 0 7 7 14 7 0 0 0 7 0 % K
% Leu: 0 14 0 7 7 7 0 7 34 7 27 7 20 0 20 % L
% Met: 7 0 0 0 7 0 0 7 7 0 0 0 0 0 0 % M
% Asn: 0 7 0 7 14 14 0 0 7 0 0 0 0 0 0 % N
% Pro: 34 0 0 7 0 7 20 0 7 40 7 20 7 7 7 % P
% Gln: 7 0 14 0 7 7 0 7 0 0 7 14 0 0 0 % Q
% Arg: 0 0 7 0 7 0 14 0 7 7 7 0 7 0 7 % R
% Ser: 0 14 0 0 34 0 0 27 7 14 0 14 14 0 20 % S
% Thr: 0 34 20 7 0 7 14 0 7 7 14 0 14 0 34 % T
% Val: 0 0 14 0 7 0 0 0 7 7 0 0 0 7 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 7 0 0 0 0 0 0 0 0 0 0 0 0 14 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _